LL-37 (5mg)

Why Buy LL-37 from Official Peptides

Official Peptides offers LL-37 at verified research purity with independent third-party HPLC documentation on every batch. We ship cold-pack from the US with same-day dispatch and maintain consistent stock. Researchers studying antimicrobial peptides, innate immunity, and host defense mechanisms choose Official Peptides for our quality standards and reliable supply.

LL-37 Research Profile

LL-37 is a 37-amino-acid human cathelicidin antimicrobial peptide (hCAP-18 C-terminal fragment) produced by neutrophils, epithelial cells, and other immune cells as part of innate host defense. It is the only known human cathelicidin and has been extensively studied for its direct antimicrobial activity against bacteria, viruses, and fungi. Beyond antimicrobial effects, research has examined LL-37’s immunomodulatory properties, wound healing promotion, angiogenic activity, and potential roles in autoimmune conditions such as psoriasis. For research use only.

Product Specifications

• Purity: ≥99% (HPLC verified)
• Format: Lyophilized powder
• Quantity: 5mg per vial
• Storage: Refrigerate at 2-8°C; protect from light
• Shipping: USPS Priority Mail with cold pack; ships within 1 business day

Frequently Asked Questions

Q: How does LL-37 kill bacteria in research models?
A: LL-37 disrupts bacterial membranes through electrostatic interaction with negatively charged bacterial lipopolysaccharide and phospholipids, followed by membrane pore formation or carpet-model disruption. This membrane-targeting mechanism makes it effective against both gram-positive and gram-negative bacteria, including many antibiotic-resistant strains studied in antimicrobial research.

Q: What immunomodulatory effects has LL-37 research documented?
A: Beyond direct killing, LL-37 research has documented effects on neutrophil lifespan extension, chemokine induction, dendritic cell maturation, mast cell activation, and wound healing through promotion of angiogenesis and keratinocyte migration. In psoriasis research, elevated LL-37 has been linked to activation of autoinflammatory pathways through nucleic acid sensing.

Q: What documentation is provided with LL-37 orders?
A: Every LL-37 batch is independently tested by a third-party laboratory. HPLC purity confirmation, identity verification by mass spectrometry, and batch-specific certificates of analysis are available on request or included with shipment.

Order LL-37 Online

Order LL-37 from Official Peptides for research-grade purity, US-based fulfillment, and quality documentation on every order. Secure checkout and free shipping over $150. Same-day dispatch available on qualifying orders.

For Research Use Only. This compound is intended strictly for in vitro laboratory research by qualified scientists. Not for human consumption. Not FDA approved. Keep out of reach of children.